AP16 capsules


It is used to strengthen the immune system in case of:

  • papilloma virus infections (HPV)
  • recurrent vulvovaginitis
  • recurrent urinary tract infections (IVU)
  • microbial ecosystem alteration(uro-genital biofilm)
  • prolonged antibiotic therapies
  • diabetes and associated dysmetabolic factors
  • stress

AP16, food supplement formulated to strengthen the immune system and promote the psychophysical well-being at every stage of life.

The most common risk factors for secondary immunosuppression are:

  • malnutrition
  • viral infections
  • lesions of the skin and mucous barrier
Vitamin C 80mg
Vitamin B5 7,5mg
Copper 0,5mg
Zinc 5mg
Bovin Colostrum 200mg
Echinacea herb Echinacea Angustifolia D.C. PLV 200mg
Lactob. Rheuterii 3MLD
Lactob. Rhamnosus 3MLD
Shitake e.s. tit 10% polysaccharides 100mg

AP16 is a complex formulation of food supplements that uses the powerful synergies among the various substances (Vitamin C, Vitamin B5, Copper, Zinc) to guarantee the genitourinary well-being through a rebalancing of the microbial ecosystem and biofilm and the reduction of oxidative stress.
The use of effective probiotics such as Lactobacilli Rhamnosus and Rheuterii on bladder and vaginal pathogens biofilm strengthens the preventive frontier, restores the vaginal ecosystem and the correct pH and reduces the need for antibiotic therapies in a much more restrictive and targeted way.
AP16 also combines in a single formulation the peculiarities of Echinacea Angustifolia and Shitake, known for their immunostimulating activity in the prevention of viral diseases.

In psychophysical vulnerability situations (nutritional deficiencies, recurrent viral infections, post-operative hospital stay) our immune system functionality is weakened: in this condition it is more difficult to defend oneself from environmental disease-causing microorganisms.
Stress refers to a dynamic process in which the homeostasis of an organism is involved, the result depends on the type, severity and duration of the stressors, on the stress responses and the organism resilience to the stress. It is important to emphasize that the relationship between stress and immune system is bidirectional, since not only stressors have an impact on immune function, but immune function changes can provoke stress responses. These two-way interactions have been identified prominently in the gastrointestinal and genital tract; the interactions between the visceral peripheral immune system and the brain take place through microbial metabolites, intestinal hormones, immune mediators and sensory neurons. These aspects of the immune stress impact on molecular processes highlight new opportunities for therapeutic intervention in association with appropriate lifestyles (regular physical activity, balanced diet, regular sleep). AP16 is recommended in case of some substances necessity, due to an improper nutrition or particular deficiency situations (recurrent infections, prolonged antibiotic therapies, surgical stress).
AP16 has an exclusive formulation created to contribute to the body well-being, optimizing the nutritional status with the supply of nutrients and substances necessary for the normal development and maintenance of the woman’s body health, at all stages of her life.

  1. Scapagnini G. Dossier scientifico sul benessere delle vie urinarie femminili. AIIPA. dicembre 2014.
  2. Graziottin A, Zanello PP, D’Errico G. Cistiti e vaginiti recidivanti: ruolo dei biofilm e delle persister cells. Dalla fisiopatologia a nuove strategie terapeutiche. Minerva Ginecologia vol. 66. N. 5. Pag.497-512. Ottobre 2014.
  3. Martina A, Magni P. Nutraceuticals and women’s health: current aspects and future perspectives. Giornale Italiano di Farmacoeconomia e Farmacoutilizzazione. 2017; 9.
  4. Calogero AE, La Vignera S, Aversa AA. Uro-andrological treatment with nutraceuticals. Giornale Italiano di Farmacoeconomia e Farmacoutilizzazione. 2017; 9 (1): 88-95.
  5. Reid G, Bruce AW. Urogenital infections in women: can probiotics help?. Postgrad Med J. 2003; 79:428–432.
  6. Elias J, Bozzo P, Einarson A. Are probiotics safe for use during pregnancy and lactation? Canadian Family Physician, Le Médecin de famille canadien, Vol 57, MARS 2011.
  7. Macklaim JM, Clemente JC, Knight R, Gloor GB, Reid G. Changes in vaginal microbiota following antimicrobial and probiotic therapy. Microbial Ecology in Health & Disease. 2015.
  8. Cai T, Tamanini I, Kulchavenya E, Perepanova T, Köves B, Wagenlehner FME, Tandogdu Z, Bonkat G, Bartoletti R, Johansen TEB. The role of nutraceuticals and phytotherapy in the management of urinary tract infections: What we need to know? Archivio Italiano di Urologia e Andrologia. 2017; 89,1.