EuPlacent

Table of active principles

It has been hypothesized that in preeclampsia an impaired placentation occurs characterised by a defective invasion of trophoblastic cells and remodeling of the uterine vascularization, resulting in reduced utero placental perfusion and activation of maternal systemic vasoconstriction associated with endothelial damage.

A defective synthesis of L-Arginine, an essential amino acid, has been documented in preeclampsia. L-Arginine, through the enzyme Nitric Oxide (NO) synthase of endothelial cells, produces Nitric Oxide, a powerful vasodilator. The Nitric Oxide plays a fundamental role in endothelial regulatory mechanisms by counteracting vasoconstriction, improving blood ow and stimulating the release of growth hormone, insulin and other very important substances for the body.

The Willow is one of the most reliable and ancient botanical medicines in the world, known to relieve mild or moderate pain and to reduce the fever since the days of Hyppocrates. When it interacts with gastric juices in the stomach, it produces an e ect that is very similar to modern aspirin but with a low incidence of side e ects. Given to its mild anti platelets property it can helps to counter the impaired placentation.

The Magnesium sulphate plays a very important role in pregnancy due to its ability to regulate uterine contractions (as it modulates muscle tone), to prevent preterm delivery (as it has a relaxing action on the uterine muscle tone) and to counteract hypertension ensuring an e ect of neonatal neuroprotection in the event of premature birth.

An inadequate Calcium level in pregnancy may have a impact on the fetus with consequent short and long e ects. Recent evidences suggest an association between low Calcium level and fetal growth restriction.
It has been observed that in populations with calcium rich diet the incidence of preeclampsia is very low. The lack of calcium may stimulates parathormone and renin synthesis with a consequent increase of intracellular calcium in the smooth muscle cells of the vessels which causes vasoconstriction.

Calcium contributes to the vascular compliance in normal pregnancy and its lack may play a role in the establishment of the the typical high resistance circulation occurring in preeclampsia.

EuPlacent is the only food supplement formulated to improve the initial phases of the embryo implantation and to counter the main obstetric complications (preeclampsia, premature delivery, recurrent pregnancy loss).

It contains high doses of L-Arginine (3g), donor of Nitric Oxide (NO) with antioxidant and vasodilator properties; Willow (320 mg), with anti-in ammatory and antiplatelet properties that regulates microcirculation and correct trophoblastic invasion, favoring implantation and counteracting the processes underlying pre-eclampsia and recurrent pregnancy loss; Magnesium sulphate (1g), with muscle relaxer propierties, which contributes to prevent both the threat of premature delivery and preeclampsia; Calcium (1g), useful for maintaining the normal arterial pressure.

EuPlacent, thanks to its exclusive formulation, helps improving the circulation of maternal blood, embryo implantation and the development process of the placenta, reducing oxidative stress and hypertensive disorders during pregnancy.

One sachet in a day in case of high risk pregnancy (advanced maternal age, twin pregnancy, IVF, history of preeclampsia, obesity, maternal autoimmune diseases, chronic hypertension, pregestational diabetes) facilitates embryo implantion, helps to prevent preeclampsia, reduces uterine hyper contractions preventing the recurrent pregnancy loss and the threat of preterm birth, ameliorates the utero-placental perfusion.

The placenta supports the fetal development during all the gestation. Placentation begins with the invasion by the trophoblast cells of the super cial decidual layer and is completed with the extension in the thickness of the uterine wall and the invasion of the deep decidua and the super cial layer of the myometrium.

During preeclampsia the typical high output, low resistance circulation seen in normal pregnancy is reversed to a low output and high systemic resistance.

Normal

The endometrium in normal pregnancy: uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and for this purpose they are remodelled into highly dilated vessels by the action of invading trophoblast (physiological change).

Preeclampsia

The endometrium in preeclampsia: a major defect in myometrial spiral artery remodeling occurs in PE with a defective interstitial trophoblast invasion.

Bibliography

  1. WHO. The world health report 2005: make every mother and child count. Geneva WHO, 2005
  2. Placental bed disorder: basic science and its translation to obstetrics, edited by R.Pijnenborg, I. Brsens, R.Romero. Cambridge University Pres, 2010
  3. Dorniak-Wall T, Grivell RM, Dekker GA, Hague W2, Dodd JM2. The role of L-arginine in the prevention and treatment of pre-eclampsia: a systematic review of randomised trials. J Hum Hypertens. 2014 Apr;28(4):230-5. doi: 10.1038/jhh.2013.100. Epub 2013 Oct 31
  4. Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol. 2018 Mar; 218(3):287-293.1
  5. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D. Magnesium sulphate for women at high risk of preterm birth for neuroprotection of the fetus. Cochrane Database of Systematic Reviews 2009, Issue 1
  6. Hofmeyr GJ, Manyame S. Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy. Cochrane Database Syst Rev. 2017 Sep 26;9:CD011192. doi: 10.1002/14651858.CD011192.pub2